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Psychological Stress and the Subsequent Appearance of New Brain MRI Lesions in MS Neurol 55:55-61, Mohr,D.C. et al, 2000 See this aricle in Pubmed Article Abstract For the total sample of patients, increased conflict and disruption in routine was followed by increased odds of developing new Gd+ brain lesions 8 weeks later (odds ratio, 1.64; p = 0.00083). There was no strong evidence of a relationship between psychological stress or distress and clinical exacerbation. These data provide support for the notion that conflict and disruption in routine are related to subsequent disease activity in MS. However, this relationship is not sufficiently robustto predict clinical exacerbations reliably in individual patients.

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